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1

Electrical circuitry in biology: emerging principles from protein structure

David Leys, Nigel S Scrutton

Journal:

Current Opinion in Structural Biology

Year:

2004

Language:

english

File:

PDF, 234 KB

english, 2004

2

Crystal structure of pentaerythritol tetranitrate reductase: “flipped” binding geometries for steroid substrates in different redox states of the enzyme

Teréz M Barna, Huma Khan, Neil C Bruce, Igor Barsukov, Nigel S Scrutton, Peter C.E Moody

Journal:

Journal of Molecular Biology

Year:

2001

Language:

english

File:

PDF, 1.45 MB

english, 2001

3

Low temperature solution behaviour of Methylophilus methylotrophus electron transferring flavoprotein: a study by analytical ultracentrifugation

H. Cölfen, S. E. Harding, Emma K. Wilson, Nigel S. Scrutton, Donald J. Winzor

Journal:

European Biophysics Journal

Year:

1997

Language:

english

File:

PDF, 330 KB

english, 1997

4

Cobalamin uptake and reactivation occurs through specific protein interactions in the methionine synthase–methionine synthase reductase complex

Kirsten R. Wolthers, Nigel S. Scrutton

Journal:

Year:

2009

Language:

english

File:

PDF, 271 KB

english, 2009

5

Examining the importance of dynamics, barrier compression and hydrogen tunnelling in enzyme catalysed reactions

Sam Hay, Nigel S. Scrutton

Journal:

Procedia Chemistry

Year:

2011

Language:

english

File:

PDF, 1.18 MB

english, 2011

6

The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease

Marta Amaral, Tiago F. Outeiro, Nigel S. Scrutton…

Journal:

Journal of Molecular Medicine

Year:

2013

Language:

english

File:

PDF, 342 KB

english, 2013

7

Good vibrations in enzyme-catalysed reactions

Hay, Sam, Scrutton, Nigel S.

Journal:

Nature Chemistry

Year:

2012

Language:

english

File:

PDF, 2.23 MB

english, 2012

8

Protein Interactions in the Human Methionine Synthase−Methionine Synthase Reductase Complex and Implications for the Mechanism of Enzyme Reactivation †

Wolthers, Kirsten R., Scrutton, Nigel S.

Journal:

Year:

2007

Language:

english

File:

PDF, 531 KB

english, 2007

9

Syntheses and electronic and optical properties of complexes of the bis(2,2′-bipyrazyl)ruthenium unit

Coe, Benjamin J., Peers, Martyn K., Scrutton, Nigel S.

Journal:

Year:

2015

Language:

english

File:

PDF, 3.47 MB

english, 2015

10

[Subcellular Biochemistry] Enzyme-Catalyzed Electron and Radical Transfer Volume 35 || Methylamine Dehydrogenase Structure and Function of Electron Transfer Complexes

Holzenburg, Andreas, Scrutton, Nigel S.

Year:

2002

Language:

english

File:

PDF, 1.46 MB

english, 2002

11

Editorial overview: Catalysis and regulation: enzyme structure, mechanism, and biosynthetic pathways

Christianson, David W, Scrutton, Nigel S

Journal:

Current Opinion in Structural Biology

Year:

2016

Language:

english

File:

PDF, 138 KB

english, 2016

12

Stepwise Hydride Transfer in a Biological System: Insights into the Reaction Mechanism of the Light-Dependent Protochlorophyllide Oxidoreductase

Archipowa, Nataliya, Kutta, Roger, Heyes, Derren, Scrutton, Nigel

Journal:

Angewandte Chemie International Edition

Year:

2018

Language:

english

File:

PDF, 5.45 MB

english, 2018

13

Degradation of explosives by nitrate ester reductases

Williams, Richard E., Rathbone, Deborah A., Moody, Peter C. E., Scrutton, Nigel S., Bruce, Neil C.

Journal:

Biochemical Society Symposium

Year:

2001

Language:

english

File:

PDF, 326 KB

english, 2001

14

Techno-economic assessment of microbial limonene production

Sun, Chenhao, Theodoropoulos, Constantinos, Scrutton, Nigel S.

Journal:

Bioresource Technology

Year:

2020

File:

PDF, 1.24 MB

2020

15

Structure-Based Insight into the Asymmetric Bioreduction of the CC Double Bond of α,β-Unsaturated Nitroalkenes by Pentaerythritol Tetranitrate Reductase

Helen S. Toogood, Anna Fryszkowska, Victoria Hare, Karl Fisher, Anna Roujeinikova, David Leys, John M. Gardiner, Gill M. Stephens, Nigel S. Scrutton

Journal:

Advanced Synthesis & Catalysis

Year:

2008

Language:

english

File:

PDF, 709 KB

english, 2008

16

Asymmetric Reduction of Activated Alkenes by Pentaerythritol Tetranitrate Reductase: Specificity and Control of Stereochemical Outcome by Reaction Optimisation

Anna Fryszkowska, Helen Toogood, Michiyo Sakuma, John M. Gardiner, Gill M. Stephens, Nigel S. Scrutton

Journal:

Advanced Synthesis & Catalysis

Year:

2009

Language:

english

File:

PDF, 442 KB

english, 2009

17

Are Environmentally Coupled Enzymatic Hydrogen Tunneling Reactions Influenced by Changes in Solution Viscosity?

Sam Hay, Christopher R. Pudney, Michael J. Sutcliffe, Nigel S. Scrutton

Journal:

Angewandte Chemie

Year:

2008

Language:

english

File:

PDF, 463 KB

english, 2008

18

Barrier Compression Enhances an Enzymatic Hydrogen-Transfer Reaction

Sam Hay, Christopher R. Pudney, Tom A. McGrory, Jiayun Pang, Michael J. Sutcliffe, Nigel S. Scrutton

Journal:

Angewandte Chemie

Year:

2009

Language:

english

File:

PDF, 443 KB

english, 2009

19

Solvent-Slaved Protein Motions Accompany Proton but Not Hydride Tunneling in Light-Activated Protochlorophyllide Oxidoreductase

Derren J. Heyes, Michiyo Sakuma, Nigel S. Scrutton

Journal:

Angewandte Chemie

Year:

2009

Language:

english

File:

PDF, 480 KB

english, 2009

20

How Does Pressure Affect Barrier Compression and Isotope Effects in an Enzymatic Hydrogen Tunneling Reaction?

Linus O. Johannissen, Prof. Nigel S. Scrutton, Prof. Michael J. Sutcliffe

Journal:

Angewandte Chemie

Year:

2011

Language:

english

File:

PDF, 454 KB

english, 2011

21

Is There a Dynamic Protein Contribution to the Substrate Trigger in Coenzyme B12-Dependent Ethanolamine Ammonia Lyase?

Dr. Alex R. Jones, Dr. Samantha J. O. Hardman, Dr. Sam Hay, Prof. Nigel S. Scrutton

Journal:

Angewandte Chemie

Year:

2011

Language:

english

File:

PDF, 508 KB

english, 2011

22

Are Environmentally Coupled Enzymatic Hydrogen Tunneling Reactions Influenced by Changes in Solution Viscosity?

Sam Hay, Christopher R. Pudney, Michael J. Sutcliffe, Nigel S. Scrutton

Journal:

Angewandte Chemie International Edition

Year:

2008

Language:

english

File:

PDF, 463 KB

english, 2008

23

Barrier Compression Enhances an Enzymatic Hydrogen-Transfer Reaction

Sam Hay, Christopher R. Pudney, Tom A. McGrory, Jiayun Pang, Michael J. Sutcliffe, Nigel S. Scrutton

Journal:

Angewandte Chemie International Edition

Year:

2009

Language:

english

File:

PDF, 443 KB

english, 2009

24

Solvent-Slaved Protein Motions Accompany Proton but Not Hydride Tunneling in Light-Activated Protochlorophyllide Oxidoreductase

Derren J. Heyes, Michiyo Sakuma, Nigel S. Scrutton

Journal:

Angewandte Chemie International Edition

Year:

2009

Language:

english

File:

PDF, 480 KB

english, 2009

25

How Does Pressure Affect Barrier Compression and Isotope Effects in an Enzymatic Hydrogen Tunneling Reaction?

Linus O. Johannissen, Prof. Nigel S. Scrutton, Prof. Michael J. Sutcliffe

Journal:

Angewandte Chemie International Edition

Year:

2011

Language:

english

File:

PDF, 444 KB

english, 2011

26

Is There a Dynamic Protein Contribution to the Substrate Trigger in Coenzyme B12-Dependent Ethanolamine Ammonia Lyase?

Dr. Alex R. Jones, Dr. Samantha J. O. Hardman, Dr. Sam Hay, Prof. Nigel S. Scrutton

Journal:

Angewandte Chemie International Edition

Year:

2011

Language:

english

File:

PDF, 491 KB

english, 2011

27

New enzymes for old: Redesigning the coenzyme and substrate specificities of glutathione reductase

Richard N. Perham, Nigel S. Scrutton, Alan Berry

Journal:

Year:

1991

Language:

english

File:

PDF, 1.09 MB

english, 1991

28

α/β Barrel evolution and the modular assembly of enzymes: Emerging trends in the flavin oxidase/dehydrogenase family

Nigel S. Scrutton

Journal:

Year:

1994

Language:

english

File:

PDF, 1.51 MB

english, 1994

29

Driving Force Analysis of Proton Tunnelling Across a Reactivity Series for an Enzyme-Substrate Complex

Parvinder Hothi, Sam Hay, Anna Roujeinikova, Michael J. Sutcliffe, Michael Lee, David Leys, Paul M. Cullis, Nigel S. Scrutton

Journal:

Year:

2008

Language:

english

File:

PDF, 310 KB

english, 2008

30

Parallel Pathways and Free-Energy Landscapes for Enzymatic Hydride Transfer Probed by Hydrostatic Pressure

Christopher R. Pudney, Tom McGrory, Pierre Lafite, Jiayun Pang, Sam Hay, David Leys, Michael J. Sutcliffe, Nigel S. Scrutton

Journal:

Year:

2009

Language:

english

File:

PDF, 605 KB

english, 2009

31

Are the Catalytic Properties of Enzymes from Piezophilic Organisms Pressure Adapted?

Sam Hay, Rhiannon M. Evans, Colin Levy, E. Joel Loveridge, Xi Wang, David Leys, Rudolf K. Allemann, Nigel S. Scrutton

Journal:

Year:

2009

Language:

english

File:

PDF, 530 KB

english, 2009

32

Biocatalysis with Thermostable Enzymes: Structure and Properties of a Thermophilic ‘ene’-Reductase related to Old Yellow Enzyme

Björn V. Adalbjörnsson, Helen S. Toogood, Anna Fryszkowska, Christopher R. Pudney, Thomas A. Jowitt, David Leys, Nigel S. Scrutton

Journal:

Year:

2010

Language:

english

File:

PDF, 830 KB

english, 2010

33

Tyrosyl Radical Formation and Propagation in Flavin Dependent Monoamine Oxidases

Rachel V. Dunn, Andrew W. Munro, Nicholas J. Turner, Stephen E. J. Rigby, Nigel S. Scrutton

Journal:

Year:

2010

Language:

english

File:

PDF, 297 KB

english, 2010

34

Focused Directed Evolution of Pentaerythritol Tetranitrate Reductase by Using Automated Anaerobic Kinetic Screening of Site-Saturated Libraries

Martyn E. Hulley, Dr. Helen S. Toogood, Dr. Anna Fryszkowska, Dr. David Mansell, Prof. Gill M. Stephens, Dr. John M. Gardiner, Prof. Nigel S. Scrutton

Journal:

Year:

2010

Language:

english

File:

PDF, 603 KB

english, 2010

35

ELDOR Spectroscopy Reveals that Energy Landscapes in Human Methionine Synthase Reductase are Extensively Remodelled Following Ligand and Partner Protein Binding

Dr. Stephen E. J. Rigby, Xiaodong Lou, Dr. Helen S. Toogood, Dr. Kirsten R. Wolthers, Prof. Nigel S. Scrutton

Journal:

Year:

2011

Language:

english

File:

PDF, 330 KB

english, 2011

36

A Site-Saturated Mutagenesis Study of Pentaerythritol Tetranitrate Reductase Reveals that Residues 181 and 184 Influence Ligand Binding, Stereochemistry and Reactivity

Dr. Helen S. Toogood, Dr. Anna Fryszkowska, Martyn Hulley, Michiyo Sakuma, Dr. David Mansell, Prof. Gill M. Stephens, Dr. John M. Gardiner, Prof. Nigel S. Scrutton

Journal:

Year:

2011

Language:

english

File:

PDF, 423 KB

english, 2011

37

Inside Cover: Focused Directed Evolution of Pentaerythritol Tetranitrate Reductase by Using Automated Anaerobic Kinetic Screening of Site-Saturated Libraries (ChemBioChem 17/2010)

Martyn E. Hulley, Dr. Helen S. Toogood, Dr. Anna Fryszkowska, Dr. David Mansell, Prof. Gill M. Stephens, Dr. John M. Gardiner, Prof. Nigel S. Scrutton

Journal:

Year:

2010

File:

PDF, 430 KB

2010

38

Chemical Aspects of Amine Oxidation by Flavoprotein Enzymes

Nigel S. Scrutton

Journal:

Year:

2005

File:

PDF, 8 KB

2005

39

ChemInform Abstract: Biocatalytic Reductions and Chemical Versatility of the Old Yellow Enzyme Family of Flavoprotein Oxidoreductases

Helen S. Toogood, John M. Gardiner, Nigel S. Scrutton

Journal:

Year:

2010

File:

PDF, 15 KB

2010

40

Analysis of Classical and Quantum Paths for Deprotonation of Methylamine by Methylamine Dehydrogenase

Kara E. Ranaghan , Laura Masgrau, Nigel S. Scrutton, Michael J. Sutcliffe, Adrian J. Mulholland

Journal:

Year:

2007

Language:

english

File:

PDF, 675 KB

english, 2007

41

Solvent as a Probe of Active Site Motion and Chemistry during the Hydrogen Tunnelling Reaction in Morphinone Reductase

Sam Hay, Christopher R. Pudney, Michael J. Sutcliffe, Nigel S. Scrutton

Journal:

Year:

2008

Language:

english

File:

PDF, 415 KB

english, 2008

42

Secondary Kinetic Isotope Effects as Probes of Environmentally-Coupled Enzymatic Hydrogen Tunneling Reactions

Sam Hay, Jiayun Pang, Phillip J. Monaghan, Xi Wang, Rhiannon M. Evans, Michael J. Sutcliffe, Rudolf K. Allemann, Nigel S. Scrutton

Journal:

Year:

2008

Language:

english

File:

PDF, 288 KB

english, 2008

43

Probing the molecular determinants of coenzyme selectivity in the P450 BM3 FAD/NADPH domain

Adrian J. Dunford, Hazel M. Girvan, Nigel S. Scrutton, Andrew W. Munro

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2009

Language:

english

File:

PDF, 646 KB

english, 2009

44

A new conceptual framework for enzyme catalysis : Hydrogen tunneling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes

Michael J. Sutcliffe, Nigel S. Scrutton

Journal:

Year:

2002

Language:

english

File:

PDF, 251 KB

english, 2002

45

Role of histidine 42 in ascorbate peroxidase : Kinetic analysis of the H42A and H42E variants

Latesh Lad, Martin Mewies, Jaswir Basran, Nigel S. Scrutton, Emma L. Raven

Journal:

Year:

2002

Language:

english

File:

PDF, 396 KB

english, 2002

46

Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1

Robert D. Finn, Jaswir Basran, Olivier Roitel, C. Roland Wolf, Andrew W. Munro, Mark J. I. Paine, Nigel S. Scrutton

Journal:

Year:

2003

Language:

english

File:

PDF, 557 KB

english, 2003

47

Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding : Relaxation kinetic studies with coenzyme analogues

Aldo Gutierrez, Andrew W. Munro, Alex Grunau, C. Roland Wolf, Nigel S. Scrutton, Gordon C. K. Roberts

Journal:

Year:

2003

Language:

english

File:

PDF, 573 KB

english, 2003

48

New insights into enzyme catalysis : Ground state tunnelling driven by protein dynamics

Nigel S. Scrutton, Jaswir Basran, Michael J. Sutcliffe

Journal:

Year:

1999

Language:

english

File:

PDF, 445 KB

english, 1999

49

Organization of the genes involved in dimethylglycine and sarcosine degradation in Arthrobacter spp. : Implications for glycine betaine catabolism

Rolandas Meskys, Richard J. Harris, Vida Casaite, Jaswir Basran, Nigel S. Scrutton

Journal:

Year:

2001

Language:

english

File:

PDF, 780 KB

english, 2001

50

Probing active site geometry using high pressure and secondary isotope effects in an enzyme-catalysed ‘deep’ H-tunnelling reaction

Sam Hay, Christopher R. Pudney, Michael J. Sutcliffe, Nigel S. Scrutton

Journal:

Journal of Physical Organic Chemistry

Year:

2010

Language:

english

File:

PDF, 209 KB

english, 2010

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